The area gets its name from the Pemigewasset River, which runs through the heart of the region. On the west side of the river runs the Wilderness trail, an old logging railroad bed. The trail starts at the Lincoln Woods trailhead where it crosses the river on a suspension bridge. There is another bridge 5 miles up that crosses west to east at the Cedar Brook trail.
There are several camping restrictions in the Pemi. No camping or fires are allowed above treeline, nor is it allowed within .25 miles of the following: 13 Falls, Thoreau Falls, Galehead Hut, Garfield Ridge Campsite, Guyot Shelter, the Willderness Trail and the East Branch of the Pemigewasset River inside the Wilderness Area. No camp site may be used by groups of more than 10 people.